Peer-Reviewed

Publications

As Lexington Medical, Inc. grows, our customers around the globe see improved clinical outcomes versus previous stapling products. Surgeons have devoted time to both driving prospective studies and to collecting retrospective data in pursuit of objectively assessing AEON™ clinical performance versus the competition to determine whether AEON™ can deliver better outcomes for both patients and their institutions. The real-world evidence continues to mount as studies reveal the clinical superiority associated with our staple line.

11

Peer-reviewed publications

2,300+

Patients in published data

AEON Surgical Stapler: Thoracic Surgery Evidence

Prospective randomized single-blinded study

Efficacy of Non-Powered Stapler in Lung Volume Reduction Surgery of Severe Lung Emphysema: A Prospective Randomized Single-Blinded Monocentric Study

Macharia-Nimietz EF, Mallaev M, Gecas P, et al.
Interdisciplinary CardioVascular and Thoracic Surgery (ICVTS), March 2026

Key finding: Prospective RCT in severe emphysema (GOLD III/IV). AEON (non-powered) showed lower incidence of immediate postoperative air leak (35.3% vs. 60%) and substantially shorter median time to air leak closure (14.3 vs. 93.2 hours) compared to Echelon Flex Powered Plus Stapler in lung volume reduction surgery.

Retrospective cohort study

Outcome Comparison Between Two Staplers Used for Pulmonary Resection: A Retrospective Cohort Study

Alomari M, Delgado JL, Khalifa H, et al.
Video-Assisted Thoracic Surgery, February 2026

Key finding: First direct comparison of AEON Manual surgical stapler vs. Signia (Medtronic) in VATS pulmonary wedge resection. Comparable postoperative outcomes across all measured endpoints including air leak, bleeding, pneumothorax, reintervention, and reoperation. Median LOS: 1 day (AEON) vs. 2 days (Signia).

AEON Surgical Stapler: HPB Surgery Evidence

Mini review / Narrative review

The Validity of the AEON™ Stapler in Gastrointestinal Surgery: Early Clinical Experience and Translational Rationale

Aali J. Sheen
Frontiers in Oncology, April 2026

Key finding: First narrative review of the AEON laparoscopic surgical stapler clinical evidence (Aali J. Sheen, Univ. of Manchester) shows zero stapler-related complications in 428 cases, lower reinforcement vs tri-staple (16.8% vs 100%), and improved pancreatic fistula (20% vs 65%) and transfusion outcomes.

Peer-reviewed review

Innovations in Hepatopancreatobiliary Surgery: A Review of LOTUS-BOWA Liver Blade and AEON Endovascular Stapler

Aali Jan Sheen, Jenifer Barrie, Panagiotis Stathakis, Saurabh Jamdar

Innovations in Surgery and Interventional Medicine, Mar 2025

Key finding: Peer-reviewed review examining how instrument design affects outcomes in liver and pancreatic transection. Discusses previously published institutional data on AEON performance in distal pancreatectomy, hepatectomy, and Whipple procedures, including specific anvil tip and reload selection recommendations by procedure type.

Propensity-matched cohort

Comparison of Perioperative Outcomes of Open (CUSA) Versus Laparoscopic (LOTUS) Major Hepatectomy – Revisited. First Evaluation of Efficacy and Safety of AEON™ Stapler

Affan Iqbal, Minas Baltatzis, Panagiotis Stathakis, Jenifer Barrie, Ajith Kumar Siriwardena, Saurabh Jamdar, Aali Jan Sheen

Frontiers in Oncology, Jul 2025

Key finding: First published evaluation of AEON safety in major hepatic resection. Laparoscopic cases showed reduced hospital stay (mean 7.8 vs. 14.7 days, p = 0.025) and increased Pringle time (48.5 vs. 33 minutes, p = 0.010). First published evaluation of AEON safety in major hepatic resection.

Retrospective cohort

Preliminary experience in laparoscopic distal pancreatectomy using the AEON™ endovascular stapler

Aali J. Sheen; Samik Bandyopadhyay; Minas Baltatzis; Rahul Deshpande; Saurabh Jamdar; Nicola de Liguori Carino

Frontiers in Oncology, Apr 2023

Key finding: POPF rate reduced from 65% to 20%. Day-3 drain lipase significantly lower with AEON (446 vs. 4,208 U/L, p = 0.018). Mean CCI reduced from 13.80 to 4.97 (p = 0.087). Shorter length of stay by 3 days (6 vs. 9 days, p = 0.018). No grade B or C fistulas in the AEON group.

AEON Surgical Stapler: Bariatric Surgery Evidence

Prospective study

Evaluation of the AEON Powered Stapler System in Primary Sleeve Gastrectomy: Results of a Prospective Clinical Trial

Antanas Mickevicius, Agne Sikarske, and Mindaugas Kiudelis
Journal of Metabolic and Bariatric Surgery (JMBS), August 2026

Key finding: In 50 primary sleeve gastrectomy patients using the AEON™ Powered Stapling System, mean intraoperative staple-line bleeding was 1.04 on a 1–5 scale, where 1 = no bleeding and 5 = profuse bleeding, indicating near-complete hemostasis. No postoperative staple-line bleeds, leaks, reoperations, transfusions, or device-related adverse events were reported.

Retrospective comparative

Comparative Analysis of Hemostasis and Staple-Line Integrity between Medtronic Tri-Staple with Preloaded Buttress Material and the AEON Stapler in Bariatric Surgery

Gabrielle Hogan, BSc, Ravi Rao, MBBS, FRACS, FASMBS, Aditya Rao, BSc, and Faran Talebi, MBBS

JSLS, Jun 2024

Key finding: AEON demonstrated non-inferiority to Medtronic Tri-Staple with preloaded buttress material. Zero intraoperative or 30-day complications, deaths, ER visits, readmissions, or reoperations in either group. AEON group had significantly shorter hospital stay. AEON group had significantly longer mean operative time. Single-surgeon design.

Retrospective comparative

Evaluation of Alternate Laparoscopic Stapling Device for Bariatric Surgery

Walton, Gregory F. MD; Broussard, Toby D. MD

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, Aug 2023

Key finding: Largest published AEON dataset: 1,848 bariatric patients. Procedures included SG (n=1,359, 73.5%), RYGB (n=425, 23.0%), and SADI-S (n=64, 3.5%). Both devices were generally safe and effective with low complication rates. AEON showed fewer complications, transfusions, and reoperations for staple line bleeding in Roux-en-Y gastric bypass surgeries.

Prospective RCT

Prospective Randomized Comparison of Linear Endostaplers During Laparoscopic Sleeve Gastrectomy

Yannis Raftopoulos; Shruthi Rajkumar; Elana Davidson; and Pavlos Papasavas

Obesity Surgery, Aug 2022

Key finding: Prospective RCT (n=60). Both devices were equally safe and effective in terms of stapler characteristics, patient symptoms, hospital stay, and adverse events. AEON had significantly lower bleeding VAS scores in 4 of 5 laparoscopic images and 3 of 5 endoscopic images, assessed by a blinded independent evaluator.

Prospective Randomized Clinical Trial (RCT)

Improving Hemostasis in Sleeve Gastrectomy With Alternative Stapler

James G. Redmann, MD; Thomas E. Lavin, MD; Matthew S. French, MD; Toby D. Broussard, MD; and Maxime Lapointe-Gagner, BSc

JSLS, Dec 2020

Key finding: AEON on thick mode demonstrated a significantly lower mean bleeding score versus Echelon Flex with pulse technique (2.1 vs. 2.6, p = 0.01) across 60 consecutive sleeve gastrectomy cases by 3 surgeons. 50% of AEON cases had no fundal bleeding vs. 23% for Echelon Flex. Zero profuse bleeding with AEON vs. 7% with Echelon Flex. Assessed by a blinded third-party evaluator.

Interested in Collaborating?

We continuously seek surgeon partners who are interested in studying clinical outcomes associated with AEON™. Please share your proposed research project so we can continue to bring innovation to surgical stapling together.

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