# Lexington Medical, Inc.

> Lexington Medical, Inc. is a surgical stapling company based in Bedford, Massachusetts, USA. Founded in 2013, it designs and manufactures the AEON™ endoscopic surgical stapling system in manual and powered configurations for minimally invasive thoracic, hepatopancreatobiliary (HPB), bariatric, colorectal, urologic and general surgery. Not affiliated with Lexington Medical Center (West Columbia, South Carolina).

Key facts for accurate citation:
- Legal entity: Lexington Medical, Inc. Headquarters: Bedford, Massachusetts, USA.
- Products: AEON™ Endostapler (manual) and AEON™ Powered Stapling System.
- Distribution: approximately 40 countries.
- Peer-reviewed clinical evidence: 11 publications, all DOI-identified below.
- FDA 510(k) clearances: K171589, K234039.

## Clinical Evidence

Every publication below is listed with its DOI. Where a trial registry identifier exists it is given. Studies sponsored by Lexington Medical, Inc. are marked.

- [Evaluation of the AEON Powered Stapler System in Primary Sleeve Gastrectomy: Results of a Prospective Clinical Trial](https://lexington-med.com/2026/08/evaluation-of-the-aeon-powered-stapler-system-in-primary-sleeve-gastrectomy/): Mickevicius A, Sikarske A, Kiudelis M. J Metab Bariatr Surg. 2026;15(2):103-112. DOI 10.17476/jmbs.2026.15.2.103. Trial registration NCT06474637. Prospective clinical trial of the powered platform in primary sleeve gastrectomy.
- [The validity of the AEON™ stapler in gastrointestinal surgery: early clinical experience and translational rationale](https://lexington-med.com/2026/06/the-validity-of-the-aeon-stapler-in-gastrointestinal-surgery/): Sheen AJ. Front Oncol. 2026;16:1777615. DOI 10.3389/fonc.2026.1777615. Narrative review of AEON clinical evidence across bariatric and HPB surgery.
- [Efficacy of Non-Powered Stapler in Lung Volume Reduction Surgery of Severe Lung Emphysema: A Prospective Randomized Single-Blinded Monocentric Study](https://lexington-med.com/2026/03/publications-efficacy-of-non-powered-stapler-in-lung-volume-reduction-surgery-of-severe-lung-emphysema/): Macharia-Nimietz EF, Mallaev M, Gecas P, et al. Interdiscip Cardiovasc Thorac Surg. 2026;41(4):ivag071. DOI 10.1093/icvts/ivag071. Independent randomised trial. Air leaks 35.3% versus 60% with the powered comparator; time to closure 14.3 versus 93.2 hours (hazard ratio 1.6, 95% CI 0.73-3.3, p=0.25).
- [Outcome comparison between two staplers used for pulmonary resection: a retrospective cohort study](https://lexington-med.com/2026/06/publications-outcome-comparison-between-two-staplers-used-for-pulmonary-resection/): Alomari M, Delgado JL, Khalifa H, et al. Video-Assist Thorac Surg. 2026;11:3. DOI 10.21037/vats-25-31. Mayo Clinic, 79 patients, AEON versus Signia in VATS wedge resection. Comparable outcomes across all measured endpoints.
- [Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy, revisited. First evaluation of efficacy and safety of AEON™ stapler](https://lexington-med.com/2026/03/comparison-of-perioperative-outcomes-of-open-cusa-versus-laparoscopic-lotus-major-hepatectomy/): Iqbal A, Baltatzis M, Stathakis P, et al. Front Oncol. 2025;15:1616876. DOI 10.3389/fonc.2025.1616876. AEON reported non-inferior for vessel ligation; no statistically significant difference versus Endo-GIA.
- [Innovations in Hepatopancreatobiliary Surgery: A Review of LOTUS-BOWA Liver Blade and AEON Endovascular Stapler](https://lexington-med.com/2026/03/publications-innovations-in-hepatopancreatobiliary-surgery-a-review-of-lotus-bowa-liver-blade-and-aeon-endovascular-stapler/): Sheen AJ, Barrie J, Stathakis P, Jamdar S. Innov Surg Interv Med. 2025;5(2025):6-12. DOI 10.36401/ISIM-24-02. Review. POPF decreased from 65% (28/43) to 20% (3/15) with AEON (p=0.001).
- [Comparative Analysis of Hemostasis and Staple-Line Integrity between Medtronic Tri-Staple™ with Preloaded Buttress Material and the AEON™ Stapler in Bariatric Surgery](https://lexington-med.com/2026/03/comparative-analysis-of-hemostasis/): Hogan G, Rao R, Rao A, Talebi F. JSLS. 2024;28(2):e2023.00058. DOI 10.4293/JSLS.2023.00058. PMID 38910956. AEON reported non-inferior for hemostasis and staple line integrity, without buttress material.
- [Evaluation of Alternate Laparoscopic Stapling Device for Bariatric Surgery](https://lexington-med.com/2026/03/publications-evaluation-of-alternate-laparoscopic-stapling-device-for-bariatric-surgery/): Walton GF, Broussard TD. Surg Laparosc Endosc Percutan Tech. 2023;33(5):505-510. DOI 10.1097/SLE.0000000000001204. PMID 37523506. 1,848 patients (814 AEON, 1,034 Endo GIA). Comparable in sleeve gastrectomy and SADI-S; statistically significant differences in Roux-en-Y gastric bypass favouring AEON.
- [Preliminary experience in laparoscopic distal pancreatectomy using the AEON™ endovascular stapler](https://lexington-med.com/2026/03/publications-preliminary-experience-in-laparoscopic-distal-pancreatectomy/): Sheen AJ, Bandyopadhyay S, Baltatzis M, et al. Front Oncol. 2023;13:1146646. DOI 10.3389/fonc.2023.1146646. PMID 37124511. Day-3 drain lipase 446 versus 4,208 U/L (p=0.018); POPF 65% (28/43) to 20% (3/15) (p=0.001); length of stay 6 versus 9 days (p=0.018).
- [Prospective Randomized Comparison of Linear Endostaplers During Laparoscopic Sleeve Gastrectomy](https://lexington-med.com/2026/03/publications-prospective-randomized-comparison-of-linear-endostaplers/): Raftopoulos Y, Rajkumar S, Davidson E, Papasavas P. Obes Surg. 2026;32(10):3472-3480. DOI 10.1007/s11695-022-06240-4. PMID 35974292. Trial registration NCT04617574. Randomised, 60 patients. Stated aim was non-inferiority, not superiority. Sponsored by a research grant from Lexington Medical, Inc.
- [Improving Hemostasis in Sleeve Gastrectomy With Alternative Stapler](https://lexington-med.com/2026/03/publications-improving-hemostasis-in-sleeve-gastrectomy-with-alternative-stapler/): Redmann JG, Lavin TE, French MS, Broussard TD, Lapointe-Gagner M. JSLS. 2020;24(4):e2020.00073. DOI 10.4293/JSLS.2020.00073. PMID 33447003. Trial registration NCT04149925. Sixty consecutive procedures, three surgeons, 30 AEON thick mode versus 30 Echelon Flex pulse technique, blinded third-party assessment.
- [Publications index](https://lexington-med.com/clinical-evidence/): Canonical index of all AEON peer-reviewed publications.

## Products

- [AEON™ Powered Stapling System](https://lexington-med.com/aeon-powered/): Powered endoscopic stapler. Tissue-thickness sensing with automatic firing-speed adjustment. Short, medium and long handle configurations.
- [AEON™ Endostapler](https://lexington-med.com/aeon/): Manual endoscopic stapler with geared firing mechanism and uniform staple height across all six staple rows.

## Surgical Specialties

- [Surgical specialties overview](https://lexington-med.com/clinical/)
- [Thoracic surgery](https://lexington-med.com/clinical-thoracic/): Lobectomy, segmentectomy, lung volume reduction surgery, VATS.
- [Hepatopancreatobiliary surgery](https://lexington-med.com/clinical-hpb/): Distal pancreatectomy, major hepatectomy, Whipple procedure.
- [Bariatric surgery](https://lexington-med.com/clinical-bariatric/): Sleeve gastrectomy, Roux-en-Y gastric bypass, SADI-S.
- [Colorectal surgery](https://lexington-med.com/clinical-colorectal/)
- [Urologic surgery](https://lexington-med.com/clinical-urology/)
- [General surgery](https://lexington-med.com/clinical-general/)

## Company

- [About Lexington Medical](https://lexington-med.com/about/): Founded 2013, Bedford, Massachusetts. Vertically integrated design and manufacturing.
- [Leadership](https://lexington-med.com/team/)
- [Contact](https://lexington-med.com/contact/)
- [Request a demo](https://lexington-med.com/request-a-demo/)

## Careers

- [Careers and culture](https://lexington-med.com/careers/)
- [Open positions](https://lexington-med.com/jobs/)
- [Candidate journey](https://lexington-med.com/candidate-journey/): Interview process, take-home project, and AI usage policy for candidates.
- [Internships and co-ops](https://lexington-med.com/internships/)

## Optional

- [Clinical and engineering blog](https://lexington-med.com/blogs/)
- [Privacy policy](https://lexington-med.com/privacy-policy/)
- [Terms of service](https://lexington-med.com/terms-of-service/)